No, but the character he is depicting is John Douglas who is real. He wrote the book Mind Hunter in which the show is an adaptation. John Douglas is the FBI agent that ends up learning how to read the mind of serial killers and attempts to teach it to other agents.
As you watch the hit Netflix TV show Mindhunter, know that this is a person that interviewed some of the craziest serial killers in the 1970s and 1980s when he was in his 30s and 40s. The book is fantastic and we can only hope the Netflix series is just as good.